Dynamics of violations the absorption function of the small intestine in conditions of acute blood loss complicated by ischemia-reperfusion of the limbs and their correction

Introduction. In the structure of modern injuries in wartime and peacetime share gunshot wounds increased significantly. The timeliness applying a tourniquet is one main methods saving lives on battlefield. patterns formation enteral insufficiency syndrome conditions acute blood loss complicated by ischemia-reperfusion limb have not been studied enough. There are no data features violations absorption function small intestine these effectiveness correction with Carbacetam, which able to reduce manifestations hemic hypoxia ischemic-reperfusion syndrome.The objective research: To establish peculiarities pathogenesis loss, their combination. evaluate Carbacetam identified abnormalities.Materials methods. experimental studies were conducted 108 white nonlinear male rats weighing 200-220 g, housed standard vivarium conditions. All animals divided into five groups: control four experimental. Under thiopental-sodium anesthesia first group was simulated limb, second – third combined. fourth group, intraperitoneally administered at dose 5 mg per kilogram animal weight. After 1 2 hours, as well after 1, 7 14 days intestines D-xylose test.The results discussion. Simulation compared causes decrease content urine day reperfusion period. Also, accompanied significant this indicator day. Until end experiment rate increases, but up does reach level control. combination starting from hour experiment, reaches minimum remains same until days. terms lowest other groups. use for corrective purposes without significantly reduces detected abnormalities more use.Conclusions. Complications experiment. intensity disorders higher Сarbacetam 7-14 period ischemia-reperfusion, correction, increase intestine. This indicates protective effect drug under pathology.